METABOLOMICS PROFILING OF AKT/C-MET-INDUCED HEPATOCELLULAR CARCINOGENESIS AND THE INHIBITORY EFFECT OF CUCURBITACIN B IN MICE

Metabolomics profiling of AKT/c-Met-induced hepatocellular carcinogenesis and the inhibitory effect of Cucurbitacin B in mice

Hepatocellular carcinoma (HCC), the most common kind of liver cancer, accounts for the majority of liver cancer diagnoses and fatalities.Clinical aggressiveness, resistance to traditional therapy, and a high mortality rate are all features of this disease.Our previous studies have shown that co-activation of AKT and c-Met induces HCC development, i

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Effectiveness of Palliative Care on Death Anxiety, Self-Compassion, and Perceived Stress in Patients with Leukemia

Objective: The current investigation examined the efficacy of palliative care in alleviating death anxiety, enhancing self-compassion, and mitigating perceived stress among patients diagnosed with leukemia.Methods: This study was executed following an experimental design that included both a control group and an experimental group across pre-test a

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Relapsed/refractory multiple myeloma-transformed plasma-cell leukemia successfully treated with daratumumab followed by autologous stem cell transplantation

Daratumumab is a humanized anti-CD38 IgG1 monoclonal antibody which could be used for multiple myeloma (MM).MM with plasma-cell leukemia (PCL) transformation is highly aggressive and is resistant to conventional therapy.Novel therapeutics are needed for PCL, and daratumumab may play role.We report a case of relapsed/refractory multiple myeloma (RRM

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